Nakamura K, Akiyama H, Tokui S, Saito K, Nitta K :A CASE OF EALES DISEASE OBSERVED BY WIDEFIELD OCTA. Retin Cases Brief Rep. 2022.
Yamashiro K, Yanagi Y, Koizumi H, Matsumoto H, Cheung CMG, Gomi F, Iida T, Tsujikawa A :Relationship between Pachychoroid and Polypoidal Choroidal Vasculopathy. J Clin Med. 11(15):4614, 2022.
Yamada C, Mukai R, Shinohara Y, Matsumoto H, Akiyama H :Occlusion of a Vortex Vein After Treatment With Half-Fluence Photodynamic Therapy Combined With Intravitreal Aflibercept Injection for Pachychoroid Neovasculopathy. Cureus. 14(8):e27663, 2022.
Saito K, Horiguchi K, Yamada S, Buyandalai B, Ishida E, Matsumoto S, Yoshino S, Nakajima Y, Yamada E, Saito T, Ozawa A, Tajika Y, Akiyama H, Yamada M :Maternal hypothyroidism is associated with M-opsin developmental delay. J Mol Endocrinol. 69(3):391-399, 2022.
Shinohara Y, Todokoro D, Yamaguchi R, Tosaka M, Yoshimoto Y, Akiyama H :Retinal ganglion cell analysis in patients with sellar and suprasellar tumors with sagittal bending of the optic nerve. Sci Rep. 12(1):11092, 2022.
Nitta K, Mukai R, Todokoro D, Akiyama H :Lacrimal Duct Obstruction and Infection Associated with Non-Traumatic Corneal Perforation: A Case Series. Int Med Case Rep J. 15:313-322, 2022.
Yamaguchi R, Tosaka M, Shinohara Y, Todokoro D, Mukada N, Miyagishima T, Akiyama H, Yoshimoto Y :Analysis of visual field disturbance in patients with sellar and suprasellar lesions: relationship with magnetic resonance imaging findings and sagittal bending of the optic nerve. Acta Neurol Belg. 122(4):1031-1041, 2022.
Matsumoto H, Hoshino J, Mukai R, Nakamura K, Akiyama H :One-year results of treat-and-extend regimen with intravitreal brolucizumab for treatment-naïve neovascular age-related macular degeneration with type 1 macular neovascularization. Sci Rep. 12(1):8195, 2022.
Kishi S, Matsumoto H :A new insight into pachychoroid diseases: Remodeling of choroidal vasculature. Graefes Arch Clin Exp Ophthalmol. 2022.
Matsumoto H, Hoshino J, Mukai R, Nakamura K, Kishi S, Akiyama H :Clinical characteristics and pachychoroid incidence in Japanese patients with neovascular age-related macular degeneration. Sci Rep. 12(1):4492, 2022.
Nitta K, Mukai R, Akiyama H :Obscured interdigitation zone at the early stage of gyrate atrophy: A case report. Am J Ophthalmol Case Rep. 25:101277, 2022.
Mukai R, Matsumoto H, Akiyama H :Risk factors for emerging intraocular inflammation after intravitreal brolucizumabinjection for age-related macular degeneration. PLoS One. 16(12):e0259879, 2021.
Kondo Y, Ozawa A, Kohno D, Saito K, Buyandalai B, Yamada S, Horiguchi K, Nakajima Y, Shibusawa N, Harada A, Yokoo H, Akiyama H, Sasaki T, Kitamura T, Yamada M :The Hypothalamic Paraventricular Nucleus Is the Center of the Hypothalamic-Pituitary-Thyroid Axis for Regulating Thyroid Hormone Levels. Thyroid. 32(1):105-114, 2022.
Kondo Y, Ozawa A, Kohno D, Saito K, Buyandalai B, Yamada S, Horiguchi K, Nakajima Y, Shibusawa N, Harada A, Yokoo H, Akiyama H, Sasaki T, Kitamura T, Yamada M The hypothalamic paraventricular nucleus is the center of the hypothalamo-pituitary-thyroid axis for regulating thyroid hormone levels. Thyroid. 2021.
Gyoten D, Ueno S, Okado S, Chaya T, Yasuda S, Morimoto T, Kondo M, Kimura K, Hayashi T, Leroy BP, Woo SJ, Mukai R, Joo K, Furukawa T Broad locations of antigenic regions for anti-TRPM1 autoantibodies in paraneoplastic retinopathy with retinal ON bipolar cell dysfunction. Exp Eye Res. 212:108770, 2021.
Shinohara Y, Mukai R, Ueno S, Akiyama H :Clinical Findings of Melanoma-Associated Retinopathy with anti-TRPM1 Antibody. Case Rep Ophthalmol Med. 2021:6607441, 2021.
Matsumoto H, Hoshino J, Mukai R, Nakamura K, Kishi S, Akiyama H :Chronic choriocapillaris ischemia in dilated vortex vein region in pachychoroid neovasculopathy. Sci Rep. 11(1):16274, 2021.
Mukai R, Matsumoto H, Akiyama H :Choroidal alterations during the clinical course of commotio retinae. Graefes Arch Clin Exp Ophthalmol. 2021.
Notomi S, Shiose S, Ishikawa K, Fukuda Y, Kano K, Mori K, Wada I, Kaizu Y, Matsumoto H, Akiyama M, Sonoda KH :Drusen and pigment abnormality predict the development of neovascular age-related macular degeneration in Japanese patients. PLoS One. 16(7):e0255213, 2021.
Matsumoto H, Hoshino J, Mukai R, Nakamura K, Kishi S, Akiyama H :Pulsation of anastomotic vortex veins in pachychoroid spectrum diseases. Sci Rep. 11(1):14942, 2021.
Todokoro D, Hosogai M, Nakano S, Akiyama H :Effective diagnosis by real-time PCR of herpes simplex diffuse endotheliitis that is similar in appearance to fungal keratitis: case series. J Ophthalmic Inflamm Infect. 11(1):20, 2021.
Ishii N, Tajika Y, Murakami T, Galipon J, Shirahata H, Mukai R, Uehara D, Kaneko R, Yamazaki Y, Yoshimoto Y, Iwasaki H :Correlative microscopy and block-face imaging (CoMBI) method for both paraffin-embedded and frozen specimens. Sci Rep. 11(1):13108, 2021.
Ando T, Kawakami H, Mochizuki K, Murata K, Manabe Y, Takagi D, Yagasaki A, Niwa Y, Yamada N, Ogura S, Matsumoto K, Morita K, Todokoro D, Kamei K :Intraocular penetration of liposomal amphotericin B after intravenous injection in inflamed human eyes. J Infect Chemother. 27(9):1319-1322, 2021.
Matsumoto H, Hoshino J, Mukai R, Nakamura K, Akiyama H :Short-term outcomes of intravitreal brolucizumab for treatment-naïve neovascular age-related macular degeneration with type 1 choroidal neovascularization including polypoidal choroidal vasculopathy. Sci Rep. 11(1):6759, 2021.
Todokoro D, Miyakubo T, Komori A, Makimura K, Akiyama H :A case of contact lens-induced fungal keratitis caused by Didymella heteroderae. Mycopathologia. 186(2):309-311, 2021.
Hoshino J, Matsumoto H, Mukai R, Nakamura K, Arai Y, Kikuchi Y, Kishi S, Akiyama H :Variation of vortex veins at the horizontal watershed in normal eyes. Graefes Arch Clin Exp Ophthalmol. 259(8):2175-2180, 2021.
Hoshino C, Konno A, Hosoi N, Kaneko R, Mukai R, Nakai J, Hirai H :GABAergic neuron-specific whole-brain transduction by AAV-PHP.B incorporated with a new GAD65 promoter. Mol Brain. 14(1):33, 2021.
Matsumoto H, Mukai R, Hoshino J, Oda M, Matsuzaki T, Ishizaki Y, Shibasaki K, Akiyama H :Choroidal congestion mouse model: Could it serve as a pachychoroid model?. PLoS One. 16(1):e0246115, 2021.
Kishimoto T, Ishida W, Nasukawa T, Ujihara T, Nakajima I, Suzuki T, Uchiyama J, Todokoro D, Daibata M, Fukushima A, Matsuzaki S, Fukuda K :In Vitro and In Vivo Evaluation of Three Newly Isolated Bacteriophage Candidates, phiEF7H, phiEF14H1, phiEF19G, for Treatment of Enterococcus faecalis Endophthalmitis. Microorganisms. 9(2):212, 2021.
Mukai R, Matsumoto H, Akiyama H :Surgical outcomes of vitrectomy for intractable diabetic macular edema. Graefes Arch Clin Exp Ophthalmol. 259(2):363-368, 2021.
Mukai R, Matsumoto H, Miyakubo T, Akiyama H :REDUCED VASCULAR DENSITY IN THE CHOROID AFTER TREATMENT WITH PHOTODYNAMIC THERAPY COMBINED WITH AFLIBERCEPT IN PATIENTS WITH POLYPOIDAL CHOROIDAL VASCULOPATHY. Retina. 41(1):156-161, 2021.
Do JR, Park SJ, Mukai R, Kim HK, Shin JP, Park DH :A 1-Year Prospective Comparative Study of Sutureless Flanged Intraocular Lens Fixation and Conventional Sutured Scleral Fixation in Intraocular Lens Dislocation. Ophthalmologica. 244(1):68-75, 2021.
Saito K, Akiyama H, Mukai R :ALTERATION OF OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN A PATIENT WITH OCULAR ISCHEMIC SYNDROME. Retin Cases Brief Rep. 15(5):588-592, 2021.
Matsumoto H, Hoshino J, Arai Y, Mukai R, Nakamura K, Kikuchi Y, Kishi S, Akiyama H :Quantitative measures of vortex veins in the posterior pole in eyes with pachychoroid spectrum diseases. Sci Rep. 10(1):19505, 2020.
Miyakubo T, Todokoro D, Satake Y, Makimura K, Miyakubo S, Akiyama H :Exophiala lecanii-corni keratitis presenting as a serpiginous pigmented superficial lesion: a case report. Medicine (Baltimore). 99(36):e22121, 2020.
Hoshi S, Todokoro D, Sasaki T :Corynebacterium Species of the Conjunctiva and Nose: Dominant Species and Species-Related Differences of Antibiotic Susceptibility Profiles. Cornea. 39(11):1401-1406, 2020.
Fujita S, Furuta N, Maruyama T, Tsukagoshi S, Nagashima K, Fujita Y, Nagai K, Kashima T, Tanaka M, Miki I, Yamazaki A, Ikota H, Oyama T, Ikeda Y :Idiopathic Orbital Inflammation Appearing on the Affected Side of Preceding Myasthenia Gravis. Intern Med. 59(14):1763-1767, 2020.
Matsumoto H, Hoshino J, Mukai R, Nakamura K, Kikuchi Y, Kishi S, Akiyama H :Vortex Vein Anastomosis at the Watershed in Pachychoroid Spectrum Diseases. Ophthalmol Retina. 4(9):938-945, 2020.
Aoki S, Nagashima K, Furuta M, Makioka K, Fujita Y, Saito K, Kashima T, Nakajima N, Ikota H, Higuchi O, Ikeda Y :Anti-LRP4 Antibody-associated Myasthenia Gravis with a Rare Complication of Thymoma Successfully Treated by Thymectomy. Intern Med. 59(9):1219-1222, 2020.
Matsumoto H, Mukai R, Kikuchi Y, Morimoto M, Akiyama H :One-year outcomes of half-fluence photodynamic therapy combined with intravitreal injection of aflibercept for pachychoroid neovasculopathy without polypoidal lesions. Jpn J Ophthalmol. 64(2):203-209, 2020.
Oda M, Yamamoto H, Matsumoto H, Ishizaki Y, Shibasaki K :TRPC5 regulates axonal outgrowth in developing retinal ganglion cells. Lab Invest. 100(2):297-310, 2020.
Miyakubo T, Mukai R, Nakamura K, Matsumoto H, Akiyama H :A Case Of Ipilimumab-Induced Unusual Serous Retinal Detachment In Bilateral Eyes. Int Med Case Rep J. 12:355-361, 2019.
Sakurada Y, Tanaka K, Miki A, Matsumoto H, Kawamura A, Mukai R, Akiyama H, Honda S, Mori R, Iijima H :Clinical characteristics of cuticular drusen in the Japanese population. Jpn J Ophthalmol. 63(6):448-456, 2019.
Matsumoto H, Kishi S, Mukai R, Akiyama H :Remodeling of macular vortex veins in pachychoroid neovasculopathy. Sci Rep. 9(1):14689, 2019.
Kishimoto T, Ishida W, Fukuda K, Nakajima I, Suzuki T, Uchiyama J, Matsuzaki S, Todokoro D, Daibata M, Fukushima A :Therapeutic Effects of Intravitreously Administered Bacteriophage in a Mouse Model of Endophthalmitis Caused by Vancomycin-Sensitive or -Resistant Enterococcus faecalis. Antimicrob Agents Chemother. 63(11):e01088-19, 2019.
Yoshida M, Hosogai M, Yokokura S, Sato K, Hariya T, Kobayashi W, Okabe T, Todokoro D, Nakazawa T :Bilateral Necrotizing Herpes Simplex Keratitis in an Immunocompetent Patient With Genetic Analysis of Herpes Simplex Virus 1. Cornea. 38(9):1185-1188, 2019.
Miyakubo T, Todokoro D, Makimura K, Akiyama H :Fungal keratitis caused by Didymella gardeniae (formerly Phoma gardeniae) successfully treated with topical voriconazole and miconazole. Med Mycol Case Rep. 24:90-92, 2019.
Todokoro D, Kamei S, Goto H, Ikeda Y, Koyama H, Akiyama H :Acute retinal necrosis following herpes simplex encephalitis: a nationwide survey in Japan. Jpn J Ophthalmol. 63(4):304-309, 2019.
Matsumoto H, Mukai R, Morimoto M, Tokui S, Kishi S, Akiyama H :Clinical characteristics of pachydrusen in central serous chorioretinopathy. Graefes Arch Clin Exp Ophthalmol. 257(6):1127-1132, 2019.
Mukai R, Park DH, Okunuki Y, Hasegawa E, Klokman G, Kim CB, Krishnan A, Gregory-Ksander M, Husain D, Miller JW, Connor KM :Mouse model of ocular hypertension with retinal ganglion cell degeneration. PLoS One. 14(1):e0208713, 2019.
Todokoro D, Suzuki T, Tamura T, Makimura K, Yamaguchi H, Inagaki K, Akiyama H :Efficacy of Luliconazole Against Broad-Range Filamentous Fungi Including Fusarium solani Species Complex Causing Fungal Keratitis. Cornea. 38(2):238-242, 2019.
Shinohara Y, Konno A, Nitta K, Matsuzaki Y, Yasui H, Suwa J, Hiromura K, Hirai H :Effects of Neutralizing Antibody Production on AAV-PHP.B-Mediated Transduction of the Mouse Central Nervous System. Mol Neurobiol. 56(6):4203-4214, 2019.
Matsumoto H, Morimoto M, Mimura K, Ito A, Akiyama H :Treat-and-Extend Regimen with Aflibercept for Neovascular Age-Related Macular Degeneration: Efficacy and Macular Atrophy Development. Ophthalmol Retina. 2(5):462-468, 2018.
Hiroe T, Kishi S :Dilatation of Asymmetric Vortex Vein in Central Serous Chorioretinopathy. Ophthalmol Retina. 2(2):152-161, 2018.
Kishi S, Matsumoto H, Sonoda S, Hiroe T, Sakamoto T, Akiyama H :Geographic filling delay of the choriocapillaris in the region of dilated asymmetric vortex veins in central serous chorioretinopathy. PLoS One. 13(11):e0206646, 2018.
Todokoro D, Eguchi H, Suzuki T, Suzuki M, Nakayama-Imaohji H, Kuwahara T, Nomura T, Tomita H, Akiyama H :Genetic diversity and persistent colonization of Enterococcus faecalis on ocular surfaces. Jpn J Ophthalmol. 62(6):699-705, 2018.
Shimizu D, Miyazaki D, Shimizu Y, Hosogai M, Kosugi I, Inoue Y :Infection of endotheliotropic human cytomegalovirus of trabecular meshwork cells. Jpn J Ophthalmol. 62(6):667-676, 2018.
Matsumoto H, Sugio S, Seghers F, Krizaj D, Akiyama H, Ishizaki Y, Gailly P, Shibasaki K :Retinal Detachment-Induced Müller Glial Cell Swelling Activates TRPV4 Ion Channels and Triggers Photoreceptor Death at Body Temperature. J Neurosci. 38(41):8745-8758, 2018.
Li D, Akiyama H, Kishi S :Optical coherence tomography patterns and outcomes of contusion maculopathy caused by impact of sporting equipment. BMC Ophthalmol. 18(1):174, 2018.
Akiyama H , Takahashi I , Shimoda Y , Mukai R , Yoshihara T , Tobita S :Ir(iii) complex-based oxygen imaging of living cells and ocular fundus with a gated ICCD camera. Photochem Photobiol Sci. 17(6):846-853, 2018.
Mukai R, Okunuki Y, Husain D, Kim CB, Lambris JD, Connor KM :The Complement System Is Critical in Maintaining Retinal Integrity during Aging. Front Aging Neurosci. 0.427083333333333, 2018.
Todokoro D, Mochizuki K, Nishida T, Eguchi H, Miyamoto T, Hattori T, Suzuki T, Inoue T, Nejima R, Hoshi S, Akiyama H :Isolates and antibiotic susceptibilities of endogenous bacterial endophthalmitis: A retrospective multicenter study in Japan. J Infect Chemother. 24(6):458-462, 2018.
Akiyama H, Li D, Shimoda Y, Matsumoto H, Kishi S :Observation of neovascularization of the disc associated with proliferative diabetic retinopathy using OCT angiography. Jpn J Ophthalmol. 62(3):286-291, 2018.
Todokoro D, Hoshino J, Yo A, Makimura K, Hirato J, Akiyama H :Scedosporium apiospermum infectious scleritis following posterior subtenon triamcinolone acetonide injection: a case report and literature review. BMC Ophthalmol. 18(1):40, 2018.
Matsumoto H, Hiroe T, Morimoto M, Mimura K, Ito A, Akiyama H :Efficacy of treat-and-extend regimen with aflibercept for pachychoroid neovasculopathy and Type 1 neovascular age-related macular degeneration. Jpn J Ophthalmol. 62(2):144-150, 2018.
Morimoto M, Matsumoto H, Mimura K, Akiyama H :Reply to the letter to the editor: Two-year results of treat-and-extend regimen with aflibercept for polypoidal choroidal vasculopathy. Graefes Arch Clin Exp Ophthalmol. 256(1):225-226, 2018.
Shinohara Y, Akiyama H, Magori M, Kishi S :Short-term outcomes after EX-PRESS implantation versus trabeculectomy alone in patients with neovascular glaucoma. Clin Ophthalmol. 11:2207-2213, 2017.
Hanyuda N, Akiyama H, Shimoda Y, Mukai R, Sano M, Shinohara Y, Kishi S :Different Filling Patterns of the Choriocapillaris in Fluorescein and Indocyanine Green Angiography in Primate Eyes Under Elevated Intraocular Pressure. Invest Ophthalmol Vis Sci. 58(13):5856-5861, 2017.
Ito A, Matsumoto H, Morimoto M, Mimura K, Akiyama H :Two-Year Outcomes of a Treat-and-Extend Regimen Using Intravitreal Aflibercept Injections for Typical Age-Related Macular Degeneration. Ophthalmologica. 238(4):236-242, 2017.
Yamashiro K, Mori K, Honda S, Kano M, Yanagi Y, Obana A, Sakurada Y, Sato T, Nagai Y, Hikichi T, Kataoka Y, Hara C, Koyama Y, Koizumi H, Yoshikawa M, Miyake M, Nakata I, Tsuchihashi T, Horie-Inoue K, Matsumiya W, Ogasawara M, Obata R, Yoneyama S, Matsumoto H, Ohnaka M, Kitamei H, Sayanagi K, Ooto S, Tamura H, Oishi A, Kabasawa S, Ueyama K, Miki A, Kondo N, Bessho H, Saito M, Takahashi H, Tan X, Azuma K, Kikushima W, Mukai R, Ohira A, Gomi F, Miyata K, Takahashi K, Kishi S, Iijima H, Sekiryu T, Iida T, Awata T, Inoue S, Yamada R, Matsuda F, Tsujikawa A, Negi A, Yoneya S, Iwata T, Yoshimura N :A prospective multicenter study on genome wide associations to ranibizumab treatment outcome for age-related macular degeneration. Sci Rep. 7(1):9196, 2017.
Nitta K, Matsuzaki Y, Konno A, Hirai H :Minimal Purkinje Cell-Specific PCP2/L7 Promoter Virally Available for Rodents and Non-human Primates. Mol Ther Methods Clin Dev. 6:159-170, 2017.
Todokoro D, Suzuki T, Kobayakawa S, Tomita H, Ohashi Y, Akiyama H :Postoperative Enterococcus faecalis endophthalmitis: virulence factors leading to poor visual outcome. Jpn J Ophthalmol. 61(5):408-414, 2017.
Morimoto M, Matsumoto H, Mimura K, Akiyama H :Two-year results of a treat-and-extend regimen with aflibercept for polypoidal choroidal vasculopathy. Graefes Arch Clin Exp Ophthalmol. 255(10):1891-1897, 2017.
Miyazaki D, Uotani R, Inoue M, Haruki T, Shimizu Y, Yakura K, Yamagami S, Suzutani T, Hosogai M, Isomura H, Inoue Y :Corneal endothelial cells activate innate and acquired arm of anti-viral responses after cytomegalovirus infection. Exp Eye Res. 161:143-152, 2017.
Hosogai M, Nakatani Y, Mimura K, Kishi S, Akiyama H :Genetic analysis of varicella-zoster virus in the aqueous humor in uveitis with severe hyphema. BMC Infect Dis. 17(1):427, 2017.
Shinohara Y, Ohtani T, Konno A, Hirai H :Viral Vector-Based Evaluation of Regulatory Regions in the Neuron-Specific Enolase (NSE) Promoter in Mouse Cerebellum In Vivo. Cerebellum. 16(5-6):913-922, 2017.
Yanagisawa K, Ogawa Y, Hosogai M, Todokoro D, Mitsui T, Yokohama A, Kishi S, Handa H :Cytomegalovirus retinitis followed by immune recovery uveitis in an elderly patient with rheumatoid arthritis undergoing administration of methotrexate and tofacitinib combination therapy. J Infect Chemother. 23(8):572-575, 2017.
Shinohara Y, Kashima T, Akiyama H, Shimoda Y, Li D, Kishi S :Evaluation of Fundus Blood Flow in Normal Individuals and Patients with Internal Carotid Artery Obstruction Using Laser Speckle Flowgraphy. PLoS One. 12(1):e0169596, 2017.
Matsuzaki Y, Konno A, Mukai R, Honda F, Hirato M, Yoshimoto Y, Hirai H :Transduction Profile of the Marmoset Central Nervous System Using Adeno-Associated Virus Serotype 9 Vectors. Mol Neurobiol. 54(3):1745-1758, 2017.
Shinohara Y, Konno A, Takahashi N, Matsuzaki Y, Kishi S, Hirai H :Viral Vector-Based Dissection of Marmoset GFAP Promoter in Mouse and Marmoset Brains. PLoS One. 11(8):e0162023, 2016.
Matsumoto H, Sato T, Morimoto M, Mukai R, Takahashi M, Hiroe T, Ehara K, Takayama M, Mimura K, Kishi S :TREAT-AND-EXTEND REGIMEN WITH AFLIBERCEPT FOR RETINAL ANGIOMATOUS PROLIFERATION. Retina. 36(12):2282-2289, 2016.
Fukuchi M, Kishi S, Li D, Akiyama H :Acute ganglion cell loss during rapid visual recovery in optic neuritis. Graefes Arch Clin Exp Ophthalmol. 254(12):2355-2360, 2016.
Todokoro D, Itakura H, Ibe T, Kishi S :Anterior Uveitis Caused by Ocular Side Effects of Afatinib: A Case Report. Case Rep Ophthalmol. 7(1):74-8, 2016.
Nitta K, Kashima T, Miura F, Hiroe T, Akiyama H, Kishi S :A Case of Blunt Trauma of the Eyeball Associated With an Inferior Oblique Muscle and an Inferior Rectus Muscle Rupture. Ophthalmic Plast Reconstr Surg. 32(5):e121-3, 2016.
Mukai Ryo, Nyamdavaa Enkhgerel, Akiyama Hideo:群馬大学医学部附属病院の眼科外来診療で認められた視神経疾患の有病率と臨床プロファイル(Prevalence and Clinical Profile of Optic Nerve Disorder Cases Seen in the Ophthalmology Outpatient Clinic of Gunma University Hospital(2016-2019))(英語). 神経眼科 38(1):68-78, 2021